March 25, 2019
NRG Oncology Broadcast archives are accessible from our website at any time. Please bookmark  this link  for your convenience.

NRG-GU006 Webinar - April 2, 3:00 pm ET
The CTSU is hosting a webinar on NCTN prostate trials, including NRG-GU006, on April 2, 2019 at 3:00 pm ET. Login to  CTSU to register (located under News and Announcements).


OTHER PROTOCOL NOTICES

1. Children’s Oncology Group Protocol AGCT1531: “A Phase III Trial of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors” is open to patient entry. It is available on the CTSU menu with Dr. Allan Covens as NRG Champion. Please enroll your eligible patients to this important trial.

Enrollment credited to NRG Oncology will count towards membership requirements.

 

2. BREAST

NRG-BR004: Memo regarding posting of the NRG-BR004 SIV and Confirmation of Completion form is posted on CTSU.

 

3. GASTROINTESTINAL

NRG-GI002: E-mail Blast (posted on CTSU)

 

4. GENITOURINARY

NRG-GU006: The CTSU is hosting a webinar on NCTN prostate trials, including NRG-GU006, on April 2, 2019 at 3:00 pm ET. Login to CTSU to register (located under News and Announcements).

 

5. GYNECOLOGIC

NRG-GY007: Currently accruing to the Phase II portion

Read more

 

Form TR for Biospecimens Shipped to NRG Biospecimen Bank-Columbus

Read more

 

Biospecimen Bank-Columbus & SDMC Undergoing Refurbishment

Read more

 

6. HEAD & NECK

NRG-HN004: Updated Protocol Overview Slides are available on the Education and Promotion tab of  CTSU.

 

7. VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on RTOG 0924, RTOG 0920, NRG-HN001, NRG-HN002, NRG-CC003, and NRG-CC004. Space is limited so register now and reserve your seat.  The next training is scheduled for Wednesday, April 10, 2019.

  

DRUG SAFETY UPDATES AND INVESTIGATOR'S BROCHURE NOTICES 

Safety updates and Investigator’s Brochure notices have been issued for the following studies:

DRUG NAME

PROTOCOL

WEBSITE FOR SAFETY REPORTS

INVESTIGATOR'S BROCHURE (IB)*

Atezolimumab

 

NRG-BR004

NRG-GI004

NRG-GY009

NRG-GY017

CTSU

CTSU

CTSU

NRG

 

Cabozantinib

NRG-GY001

CTSU

 

Ipilimumab

 

NRG-BN002

NRG-GY003

NRG

NRG

X

X

Nivolumab

NRG-BN002

NRG-GY003

NRG

NRG

 

Pembrolizumab

NRG-GI002

NRG-GY016

NRG-HN003

CTSU

CTSU

NRG

 

Pertuzumab and Trastuzumab

NRG-BR004

NSABP B-52

CTSU

CTSU

 

Trastuzumab

NSABP B-43

NSABP B-47

CTSU

CTSU

 

 

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Online Agent Order Processing (OAOP) website ( https://ctepcore.nci.nih.gov/OAOP/). Log-in using your Identity and Access Management (IAM) username and password credentials and provide the requested information to access the document.

 

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).

 

 

 

 

Prophylactic Cranial Irradiation Improves Disease-free Survival and Brain Metastases Rates for Locally Advanced Non-small Cell Lung Cancer

Prophylactic cranial irradiation (PCI), a technique used to prevent the clinical development of brain metastases, is established as a standard approach for many patients with small cell lung cancer (SCLC) after initial therapy. While studies established that PCI decreases the incidence of brain metastases for patients with locally advanced non-small cell lung cancer (LA-NSCLC), there is no established indication for its use for such NSCLC patients.  Read more



Biospecimen Bank-San Francisco closure on March 29th

The NRGBB-San Francisco will be CLOSED for business on Friday, March 29 in observance of the UCSF Cesar Chavez Day Sprint Holiday. Sites should only ship frozen specimens from Monday, March 25 – Tuesday, March 26 of that week to avoid any potential delays in shipping. FFPE shipments can be made on any day that week. Please contact the bank with any questions at  NRGBB@ucsf.edu.

NRG Oncology is pleased to report the scientific articles and abstracts that have appeared or have been presented during the previous week. This publications report includes links, when available, to the article, PubMed abstract, or association abstract.


JOURNAL ARTICLES

Beitler JJ, Switchenko JM, Dignam JJ, McDonald MW, Saba NF, Shin DM, Magliocca KR, Cassidy RJ, El-Deiry MW, Patel MR, Steuer CE, Xiao C, Hudgins PA, Aiken AH, Curran WJ Jr, Le QT. Smoking, age, nodal disease, T stage, p16 status, and risk of distant metastases in patients with squamous cell cancer of the oropharynx. Cancer. 2019 Mar 1;125(5):704-711. doi: 10.1002/cncr.31820. Epub 2018 Dec 11. PubMed PMID: 30548235.   Read more

Dawson LA, Winter KA, Katz AW, Schell MC, Brierley J, Chen Y, Kopek N, Crane CH, Willett CG. NRG Oncology/RTOG 0438: A Phase I Trial of Highly Conformal Radiation Therapy for Liver Metastases. Pract Radiat Oncol. 2019 Feb 27. pii: S1879-8500(19)30067-0. doi:  10.1016/j.prro.2019.02.013. [Epub ahead of print] PubMed PMID: 30825666.   Read more


Kavanaugh JA, Holler S, DeWees TA, Robinson CG, Bradley JD, Iyengar P, Higgins KA, Mutic S, Olsen LA. Multi-Institutional Validation of a Knowledge-Based Planning Model for Patients Enrolled in RTOG 0617: Implications for Plan Quality Controls in Cooperative Group Trials. Pract Radiat Oncol. 2019 Mar;9(2):e218-e227. doi: 10.1016/j.prro.2018.11.007. Epub 2018 Dec 15. PubMed PMID: 30562615.   Read more


Kim RS, Song N, Gavin PG, Salgado R, Bandos H, Kos Z, Floris G, Eynden GGVD, Badve S, Demaria S, Rastogi P, Fehrenbacher L, Mamounas EP, Swain SM, Lawrence Wickerham D, Costantino JP, Paik S, Wolmark N, Geyer CE, Lucas PC, Pogue-Geile KL. Stromal Tumor-infiltrating Lymphocytes in NRG Oncology/NSABP B-31 Adjuvant Trial for Early-stage HER2-positive Breast Cancer. J Natl Cancer Inst. 2019 Mar 19. pii: djz0325. [Epub ahead of print] PubMed PMID: 30888406.   Read more


Lieberman FS, Wang M, Robins HI, Tsien CI, Curran WJ Jr, Werner-Wasik M, Smith RP, Schultz C, Hartford AC, Zhang P, Mehta MP. Phase 2 Study of Radiation Therapy Plus Low-Dose Temozolomide Followed by Temozolomide and Irinotecan for Glioblastoma: NRG Oncology RTOG Trial 0420. Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):878-886. doi: 10.1016/j.ijrobp.2018.11.008. Epub 2018 Nov 27. PubMed PMID: 30496882.  Read more


Sun A, Hu C, Wong SJ, Gore E, Videtic G, Dutta S, Suntharalingam M, Chen Y, Gaspar LE, Choy H. Prophylactic Cranial Irradiation vs Observation in Patients With Locally Advanced Non-Small Cell Lung Cancer: A Long-term Update of the NRG Oncology/RTOG 0214 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2019 Mar 14. doi: 10.1001/jamaoncol.2018.7220. [Epub ahead of print] PubMed PMID: 30869743.   Read more


PUBLICATIONS REMINDERS

Please note the following upcoming meeting and abstract submission deadline dates

 

Upcoming Meetings

American Association for Cancer Research (AACR); Mar 29 - Apr 3, 2019; Atlanta, GA

European Society for Radiotherapy and Oncology (ESTRO); Apr 26-30, 2019; Milan, Italy

Society of Surgical Oncology (SSO); Mar 27-30, 2019 ; San Diego, CA


Upcoming Abstract Submission Deadlines

ESMO Breast Cancer Annual Congress; May 2-4, 2019; Berlin, Germany; LBA deadline Apr 1, 2019 noon CEST (Central European Summer Time)

European Society of Gynaecolocial Oncology (ESGO) Biennial; Nov 2-5, 2019; Athens, Greece; due to publications committee Apr 19, 2019; meeting submission deadline May 3, 2019

European Society for Medical Oncology (ESMO); Sep 27-Oct 1, 2019; Barcelona, Spain; due to publications committee Apr 30, 2019; meeting submission deadline May 8, 2019 9 pm CEST (Central European Summer Time); LBA Aug 21, 2019 9:00 pm CEST

International Society for Quality of Life Research (ISOQOL); Oct 20-23, 2019; San Diego, CA; due to publications committee Mar 26 2019; meeting submission deadline Apr 8, 2019

Radiological Society of North America (RSNA); Dec 1-6, 2019; Chicago, IL; due to publications committee Mar 27 2019; meeting submission deadline Apr 10, 2019

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